Electromagnetic Field Stimulation Effects on Intrinsically Disordered Proteins and Their Role in Aging and Neurodegeneration

Authors: Perez FP, Bandeira J, Morisaki J, Kanakri H, Rizkalla M

Year: 2025 Oct

Category: Biophysics

Journal: J Biomed Sci Eng

DOI: 10.4236/jbise.2025.1810030

URL: https://www.scirp.org/journal/paperinformation?paperid=146794

Abstract

Overview

There is increasing evidence from preclinical studies in cell cultures and small organisms that exposure to Electromagnetic Fields (EMFs) produces beneficial biological effects. However, controversy persists due to the absence of a clearly defined mechanism.

Mechanisms Discussed

  • Classical physics cannot fully explain EMF bioeffects due to the non-ionizing nature of these exposures.
  • Emerging studies indicate mediation by quantum mechanical phenomena, especially quantum tunneling and particle-wave duality affecting the water-protein interface.

Findings

  • Evidence is presented of EMF-induced conformational changes in Intrinsically Disordered Proteins (IDPs), including beta-amyloid, tau, alpha-synuclein, and Heat Shock Factor 1 (HSF1).
  • Experimental data reveal specific RF frequencies and SAR levels that activate proteostasis and autophagy in cell cultures and animal models.
  • Variables like frequency, intensity, Specific Absorption Rate (SAR), exposure time, polarization, phase, pulse modulation, and scheduling impact experimental outcomes.

Conclusion

These findings offer a new biophysical and quantum framework for understanding EMF bioeffects. The results open promising avenues for research in biophysics and quantum biology, with potential applications in humans that align with regulatory safety thresholds.

electromagnetic fields intrinsically disordered proteins neurodegeneration aging quantum biology proteostasis autophagy
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