835 MHz RF-EMF decreases expression of calcium channels, inhibits apoptosis, but induces autophagy in mouse hippocampus

Abstract

Overview

The research investigates the impact of radiofrequency electromagnetic fields (RF-EMF) on the central nervous system (CNS), specifically focusing on the hippocampus of C57BL/6 mice. This study is relevant due to the increasing use of mobile communications and the potential health risks associated with RF-EMF exposure.

Findings

• Exposure to 835 MHz RF-EMF at a specific absorption rate (SAR) of 4.0 W/kg over 4 weeks significantly reduced the expression of voltage-gated calcium channels (VGCCs) in the hippocampus. VGCCs are crucial for the entry of calcium ions into cells.
• Visibly increased accumulation of autolysosomes in hippocampal neurons, alongside significant uplift in the expression of autophagy-related genes and proteins, such as LC3B-II.
• Decreased activation in the apoptotic pathway, which may be linked to reduced calcium channel expression and subsequent decreased calcium levels in neurons.

Conclusion

Exposure to RF-EMF can alter intracellular calcium homeostasis by decreasing calcium channel expression in the hippocampus. This change likely activates autophagy pathways and inhibits apoptotic processes as an adaptation to 835 MHz RF-EMF exposure, indicating potential health risks that need to be carefully evaluated.