Abstract

Overview of the Study

We examined the impact of 835 MHz radiofrequency electromagnetic fields (RF-EMFs) on neuronal functions in mice, with a specific focus on alterations in synaptic vesicles (SVs). These vesicles are essential for storing neurotransmitters at synaptic boutons or axon terminals.

Methodology

The study included C57 BL/6 mice exposed to RF-EMF (4.0 W/kg specific absorption rate) for 5 hours daily. We utilized advanced electron microscopy methods to observe changes in the cortical neurons' ultrastructure.

Key Findings

• Decreased density of SVs in the presynaptic boutons of cortical neurons was significant post RF-EMF exposure.
• There was a notable reduction in the expression of synapsins I/II genes and proteins in the cortical neurons of exposed mice.

Conclusion

The exposure to RF-EMF resulted in structural and functional changes in synaptic vesicles, potentially affecting neurotransmitter levels in the cerebral cortex. This could have implications for neuronal function and health, underscoring the need for further studies on RF-EMF's effects on the brain.