ELF EMF promotes astrocytic differentiation of human bone marrow stem cells by modulating SIRT1 expression

Authors: Jeong WY, Kim JB, Kim HJ, Kim CW

Year: 2017 Mar 29

Category: Biotechnology and Biochemistry

Journal: Biosci Biotechnol Biochem

DOI: 10.1080/09168451.2017.1308243

URL: https://www.ncbi.nlm.nih.gov/pubmed/28351214

Abstract

Overview

This study explores the influence of extremely low-frequency electromagnetic fields (ELFMF) on the fate and differentiation of cells, with a specific focus on astrocytic differentiation promoted through modulation of SIRT1 expression.

Findings

  • ELFMF exposure reduces cell proliferation while promoting astrocytic differentiation.
  • Increased levels of the astrocyte marker GFAP were observed, alongside decreased levels of Nestin and OCT3/4, indicating a shift towards astrocytic traits.
  • Significantly elevated reactive oxygen species (ROS) levels post-ELFMF exposure underline the role of oxidative stress in astrocytic differentiation.
  • SIRT1 activation and its downstream molecules (TLE1, HES1, MASH1) play crucial roles in this differentiation process, modulated via ELFMF.

Conclusion

ELFMFs potentially enhance astrocytic differentiation by activating SIRT1 and altering expressions of related molecules, pointing towards notable implications for their use in biomedical applications and highlighting the health risks associated with ELFMF exposure.

ELF EMF astrocytic differentiation stem cells SIRT1 expression health risks
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