ELF EMF induces neural differentiation of hBM-MSCs through regulation of (Zn)-metallothionein-3

Authors: Aikins AR, Hong SW, Kim HJ, Yoon CH, Chung JH, Kim M, Kim CW

Year: 2017 Mar 29

Category: Bioelectromagnetics

Journal: Bioelectromagnetics

DOI: 10.1002/bem.22046

URL: https://www.ncbi.nlm.nih.gov/pubmed/28370392

Abstract

Overview

This study examines the effects of extremely low-frequency electromagnetic field (ELF EMF) on neural differentiation in human bone marrow-derived mesenchymal cells (hBM-MSCs), with implications for neurodegenerative diseases like Alzheimer's disease (AD).

Findings

  • ELF EMF exposure leads to decreased proliferation and enhanced neural-like morphology in hBM-MSCs.
  • Significant expression of neuronal markers (β-tubulin3, pleiotrophin, and neurofilament-M at the mRNA level and MAP2 at the protein level) were observed post-exposure.
  • There is a decrease in metal-response element-transcription factor 1 and MT3 expression, along with a decreased intracellular Zinc concentration.
  • Regulatory mechanism for MT3 was suggested during the neural differentiation process.
  • Additionally, upregulation of dihydropyrimidinase-related protein 2 and no change in γ-enolase expression were recorded.

Conclusion

The findings highlight a potential regulatory mechanism involving MT3 during the neural differentiation of hBM-MSCs induced by ELF EMF. These insights are critical for developing new treatments for neurodegenerative diseases.

ELF EMF neural differentiation hBM-MSCs neurodegenerative diseases Alzheimer's disease zinc homeostasis metallothionein-3
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