Impact of Cerebral Radiofrequency Exposures on Oxidative Stress and Corticosterone in a Rat Model of Alzheimer's Disease

Authors: Bouji M, Lecomte A, Gamez C, Blazy K, Villégier AS

Year: 2019 Nov 25

Category: Neuroscience

Journal: J Alzheimers Dis

DOI: 10.3233/JAD-190593

URL: https://www.ncbi.nlm.nih.gov/pubmed/31796670

Abstract

Abstract Summary of the Study

Overview: Alzheimer's disease (AD) is the predominant neurodegenerative disorder leading to dementia. This study explores the effects of mobile phone RF-EMF exposures on memory alterations linked to AD in rodents.

Objective: The research aimed to verify if RF-EMF exposure influences memory through alterations in corticosterone levels and oxidative stress in rats modeled with Alzheimer's disease.

Methods:

  • Rats were infused with compounds to simulate AD or given a control treatment.
  • Exposure to RF-EMF mimicked typical cell phone usage.
  • High brain averaged specific absorption rates (BASAR) were tested to determine hazard thresholds.

Findings:

  • Similar corticosterone levels were observed between groups.
  • Impaired memory performances and increased brain markers related to AD were noted, particularly under higher RF-EMF exposures.
  • Control rats showed increases in oxidative stress markers without memory modification.

Conclusion: The study indicates a potential increase in brain vulnerability to oxidative damage from RF-EMF in an Alzheimer's disease model. Although memory was not significantly altered, enhanced risk associated with higher RF-EMF exposure was evident, especially for subjects with neurodegenerative conditions.

Alzheimer's disease Radiofrequency electromagnetic fields Oxidative stress Corticosterone Rat model Memory impairment Neurodegenerative disease
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