Abstract

Abstract Summary

Overview

Purpose of this study was to investigate the effects of radiofrequency electromagnetic fields (RF-EMF), similar to those from heavy cell phone use, on in vivo C6 brain tumors in Wistar rats.

Methods

• Controlled brain averaged specific absorption rate (BASAR) exposure levels were administered: GSM 900 MHz at 0 (sham), 0.25, or 0.5 W/kg.
• Treatment was applied 5 days a week, 45 minutes each day in restraint, alongside cage controls.
• Assessment at death included tumor volume, immunohistochemistry for vascularization, apoptosis, cell division, immune cell invasion, necrosis, and mitotic index.

Findings

No effect of BASAR on survival, tumor volume, mitotic index, vascularization, infiltration, necrosis, or cell division was observed. However, a BASAR-dependent reduction in immune cell invasion and apoptosis was noted, suggesting subtle impacts of RF-EMF.

Conclusion

The study indicates potential influences of RF-EMF on immune cell behavior and apoptosis in glioblastoma cells, although these effects did not extend to overall survival. Further research is required to substantiate these findings.