The dose-dependent effect of 1.5-GHz microwave exposure on spatial memory and the NMDAR pathway in Wistar rats

Authors: Wang H, Song L, Zhao L, Wang H, Xu X, Dong J, Zhang J, Yao B, Zhao X, Peng R

Year: 2022 Dec 27

Category: Environmental Science

Journal: Environmental Science Pollution Research International

Institution: Environ Sci Pollut Res Int

DOI: 10.1007/s11356-022-24850-4

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9792922/

Abstract

Overview

The study investigates the impacts of 1.5-GHz microwave exposure on various biological functions in Wistar rats, focusing on cognitive abilities and brain structure.

Findings

  • Exposure to microwave radiation was conducted at different power densities showcasing a dose-dependent effect on the rats.
  • Variables observed included spatial memory, EEG activity, hippocampal structure, and NMDAR signalling pathway proteins.
  • Impairments: Higher doses (30 and 50 mW/cm2) resulted in significant negative effects on spatial memory and brain structure.
  • Protein Changes: Alterations in NMDAR subunits and related signaling molecules were noted, indicating potential damage to neural pathways.

Conclusion

Exposure to 1.5-GHz microwaves at varying power densities conclusively affects spatial memory and hippocampal structure in a dose-dependent manner. Higher energy exposures led to more severe changes, underlining potential risks associated with electromagnetic radiation exposure.

microwave radiation spatial memory NMDAR pathway Wistar rats cognitive functions
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