Exposure to Electromagnetic Fields from Mobile Phones and Fructose consumption Coalesce to Perturb Metabolic Regulators AMPK/SIRT1-UCP2/FOXO1 in Growing Rats

Abstract

Overview

Objective: In this study, the combined effect of electromagnetic fields (EMFs) from mobile phones and fructose consumption on key metabolic regulators in growing rats was investigated. The study aimed to uncover the molecular mechanisms underlying insulin resistance induced by these environmental factors.

Methods

• Weaned Wistar rats were divided into four groups: Normal, Exposure Only (ExpO), Fructose Only (FruO), and Exposure and Fructose (EF).
• All groups had access to standard laboratory chow, with variations in fructose solution access and EMF exposure for 8 weeks.
• Mitochondrial function, insulin receptor signaling, and oxidative stress markers in hypothalamic and hepatic tissues were analyzed.

Findings

Significant decreases in metabolic and oxidative stress markers were observed in the EF group, indicating disrupted insulin signal crosstalk and mitochondrial function.

Conclusion

The study concludes that simultaneous exposure to EMFs and high fructose intake during critical growth periods adversely affects metabolic functions, reinforcing the need for guidelines to mitigate these exposures in young populations.