Effect of Luteolin on Biochemical, Immunohistochemical, and Morphometrical Changes in Rat Spinal Cord following Exposure to a 900 MHz Electromagnetic Field

Authors: Ahmad Yahyazadeh, Berrin Zuhal Altunkaynak

Year: 2020 Aug 20

Category: Biomedical Sciences

Journal: Biomed Environ Sci

Institution: Biomed Environ Sci

DOI: 10.3967/bes2020.078

URL: http://www.besjournal.com/en/article/doi/10.3967/bes2020.078

Abstract

Overview

This study investigates the effects of exposure to a 900 MHz electromagnetic field (EMF) on the cervical spinal cord of rats and evaluates the protective potential of luteolin against tissue damage.

Methods

Stereological, biochemical, immunohistochemical, and histopathological techniques were employed to gather quantitative data.
Parameters studied included morphometric values, superoxide dismutase (SOD) levels, expression of high-mobility group box 1 protein molecules, and histological changes.

Findings

The findings highlight a significant decrease in motor neurons in rats exposed to EMF compared to the control group, indicating a potential health risk from EMF exposure. Conversely, rats treated with luteolin exhibited an increased count of motor neurons and reduced SOD enzyme activity, suggesting that luteolin could mitigate EMF-induced oxidative stress and damage.

Conclusion

The exposure to EMF could pose a risk to cervical spinal cord tissues. Luteolin has demonstrated effectiveness in reducing the adverse effects of EMF by alleviating oxidative stress.

EMF spinal cord rats luteolin neuroprotection oxidative stress

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