New view on the impact of the low-frequency electromagnetic field (50 Hz) on stress responses - hormesis effect

Authors: Klimek A, Kletkiewicz H, Siejka A, Wyszkowska J, Maliszewska J, Klimiuk M, Jankowska M, Seckl J, Rogalska J

Year: 2022 Nov 2

Category: Neuroendocrinology

Journal: Neuroendocrinology

DOI: 10.1159/000527878

URL: https://pubmed.ncbi.nlm.nih.gov/36323227/

Abstract

Overview

This study explores how low-frequency electromagnetic fields (50 Hz) impact neurally regulated stress responses, focussing on the hypothalamic-pituitary-adrenal (HPA) axis dynamics influenced by electromagnetic field (EMF) exposure.

Methods

  • Adult rats were exposed to EMF at intensities of 1 mT and 7 mT for one hour per day over a seven-day period, repeated three times.
  • In-depth analysis of HPA axis hormones and receptors post-exposure.
  • Evaluation of hormonal and behavioral responses to a subsequent stress test (open-field test) after EMF exposure.

Findings

Key Observations: - EMF exposure establishes a new set-point for HPA axis activity, with the effect's nature varying with EMF intensity and exposure frequency.

Specific Results: - 1 mT EMF triggers an adaptive stress response.

- 7 mT EMF results in sensitization and increased vulnerability to subsequent stress factors.

- Increased MR mRNA abundance in hippocampal regions of rats exposed to 1 mT EMF hints at potential neuroprotective effects and therapeutic implications of EMFs.

Conclusion

The study suggests a significant link between EMF exposures and modulation of neuroendocrine functions, indicating the need for careful evaluation of EMF effects on health, particularly given the potential therapeutic applications and risks.

EMF hormesis effect stress response HPA axis neuroprotection electromagnetic fields rat study
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