Suppression of Glucocorticoid Response in Stressed Mice Using 50 Hz Electric Field According to Immobilization Degree and Posture

Abstract

Overview

This research investigates the impact of 50 Hz electric fields (EFs) on stress-induced glucocorticoid responses in mice, considering different postures and levels of immobilization.

Findings

• The study involved immobilizing BALB/c mice in centrifuge tubes, positioning them in either abdominal or lateral recumbent positions, and exposing them to ELF EF between parallel plate electrodes.
• Blood samples were collected post exposure while the mice were under anesthesia, and plasma glucocorticoids levels assessed.
• The research demonstrated that ELF EF could suppress glucocorticoid increase due to immobilization stress, showing reproducibility in both moderately and mildly stressed mice, but not in severely immobilized mice.
• This variability underscores the crucial role of stress degree adjustment for consistent outcomes in this model.

Conclusion

The study highlights significant implications of ELF EF on homeostasis and stress response, providing essential insights for evaluating biological risks and potential medical applications of ELF electric fields.