Computational modeling of the variation of the transmembrane potential of the endothelial cells of the blood-brain barrier subject to an external electric field

Abstract

Overview

The study explores the electromechanical properties of endothelial cells that form the blood-brain barrier, focusing on the impact of external electric fields on these cells.

Findings

• The interaction between extremely low frequency (ELF) electric fields and the electrical activity of the cells was examined.
• The study modeled the mechanical effect of these fields on the capacitance of the cell membrane, incorporating this dynamic in the parallel conductance model.
• Results indicate that ELF electric fields cause hyperpolarization, influencing the release of nitric oxide and the polymerization of actin filaments within the cells.

Conclusion

The induced changes in cell behavior due to ELF fields could significantly affect the permeability of the blood-brain barrier and enhance drug delivery to the central nervous system.