Abstract

Overview

The electromechanical properties of the membrane of endothelial cells forming the blood-brain barrier are critical to its function. This study investigates the impact of extremely low frequency (ELF) external electric fields on these cells.

Findings

• ELF electric fields influence the electrical properties of the cell membrane by altering its capacitance.
• This change in capacitance affects the electrical activity of the cells, leading to hyperpolarization.
• Hyperpolarization has an indirect effect on the release of nitric oxide and the polymerization of actin filaments within the endothelial cells.

Conclusion

The interaction between ELF electric fields and the blood-brain barrier's endothelial cells could significantly affect the barrier's permeability and has potential implications in central nervous system drug delivery.