Effects of power-frequency MF on cardiomyocytes differentiated from human induced pluripotent stem cells

Authors: Takahashi M, Saito A, Jimbo Y, Nakasono S

Year: 2017

Category: Toxicology

Journal: J Toxicol Sci

Institution: J Toxicol Sci

DOI: 10.2131/jts.42.223

URL: https://www.ncbi.nlm.nih.gov/pubmed/28321048

Abstract

Overview

Human cardiomyocytes derived from pluripotent stem cells offer new insights into the effects of power-frequency magnetic fields on cardiac electrical activity, diverging from studies reliant on non-human models and theoretical human estimations.

Findings

  • Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are applied to examine responses to cardioactive influences, including electromagnetic fields.
  • In this investigation, hiPSC-CMs were exposed to a 50 Hz magnetic field at 400 mT; conditions under which the study was conducted did not demonstrate a significant impact on electrical activity, as measured by field potential durations.

Conclusion

Short-term exposure to a 50 Hz, 400 mT magnetic field does not appear to affect the electrical activity of cardiomyocytes derived from human induced pluripotent stem cells under the specific conditions tested, indicating potential safety under these exposure conditions. However, thorough investigations over varying conditions and long-term effects are essential to full understanding and safety validations.

cardiomyocytes human induced pluripotent stem cells magnetic fields electrical activity toxicology
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