Abstract

Overview

The study investigates the potential health risks associated with exposure to power-frequency magnetic fields (MFs), particularly in relation to childhood leukemia and B-cell differentiation from human hematopoietic stem/progenitor cells (HSPCs).

Methodology

A refined in vitro protocol was utilized to expose human HSPCs to 300 mT of 50 Hz MF for 35 days to assess early B-cell differentiation. In a controlled, blinded experimental setup, the process was monitored, comparing the exposed group to a control group.

Findings

• No significant changes were observed in the percentages of myeloid or lymphoid cells and their degree of differentiation from pro-B to immature-B cells between the MF-exposed group and the control group.
• Similar levels of recombination-activating gene (RAG)1 and RAG2 expression were noted in both groups, indicating no impact of MF exposure on these genes.

Conclusion

Exposure to 50 Hz magnetic field at 300 mT does not appear to adversely affect the differentiation of B cells from human hematopoietic stem cells. This study contributes to understanding the implications of electromagnetic field exposure on childhood leukemia risks and cellular differentiation, emphasizing the need for further research in this area.