Immunomodulatory role of non-ionizing electromagnetic radiation in human leukemia monocytic cell line

Authors: Yadav H, Singh R.

Year: 2023 May 17

Category: Environmental Science

Journal: Environ Pollut

DOI: 10.1016/j.envpol.2023.121843

URL: https://pubmed.ncbi.nlm.nih.gov/37207815/

Abstract

Overview

The study investigates the interaction of radiofrequency radiation (RFR) with the immune system, particularly focusing on human leukemia monocytic cell lines. This research gains importance as the World Health Organization recognizes RFR as a type of environmental energy affecting human physiological functions.

Findings

Human leukemia monocytic cell lines were exposed to 2318 MHz RFR from mobile phones, with a power density of 0.224 W/m2 over varying time durations (15, 30, 45, 60, 90, and 120 minutes).
Pro-inflammatory cytokine production: Increase in IL-1α level and reactive species such as nitric oxide and superoxide after 30 minutes of exposure.
Phagocytic activity: Reduced activity observed after 60 minutes of exposure but normal functioning restored at 120 minutes.
No significant impact on cell viability or TNF-α level was noted.

Conclusion

The results suggest a complex time-dependent immunomodulatory effect of RFR in human leukemia monocytic cells. Although short-term effects were observed, further research is needed to understand the long-term effects and mechanisms.

electromagnetic radiation immunomodulation human health leukemia radiofrequency radiation cell studies immune response

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