Immunomodulatory role of non-ionizing electromagnetic radiation in human leukemia monocytic cell line

Authors: Yadav H, Singh R.

Year: 2023 May 17

Category: Immunology

Journal: Environ Pollut

DOI: 10.1016/j.envpol.2023.121843

URL: https://pubmed.ncbi.nlm.nih.gov/37207815/

Abstract

Overview

In contemporary daily life, exposure to radiofrequency radiation (RFR) is ubiquitous, raising significant medical and scientific inquiry, particularly after the WHO's classification of these radiations. This study explores the immunomodulatory impacts of RFR from mobile phones on human leukemia monocytes.

Findings

  • The human leukemia monocytic cell lines were exposed to RFR of 2318 MHz and a power density of 0.224 W/m2 at various intervals.
  • Enhancement in pro-inflammatory cytokine IL-1α and reactive species such as nitric oxide and superoxide was observed after 30 minutes of exposure.
  • A noticeable reduction in phagocytic activity of monocytes was evident at 60 minutes of exposure.
  • Cells restored normal functions after prolonged exposure (120 min).

Conclusion

The results underscore a distinct time-dependent immunomodulatory effect of RFR in monocytes. However, significant gaps remain in understanding the long-term effects and mechanisms, necessitating further research.

electromagnetic radiation human health immunomodulation leukemia cell line
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