Electromagnetic fields may act via calcineurin inhibition to suppress immunity, thereby increasing risk for opportunistic infection: Conceivable mechanisms of action

Abstract

Overview

The study explores whether prolonged exposure to man-made electromagnetic fields (EMFs) can suppress immune function by affecting the enzyme calcineurin, which is crucial for activating T-cells in the immune system.

Findings

• Long-term EMF exposure might lead to immunosuppression through the inhibition of calcineurin.
• Calcineurin inhibitors like cyclosporine are known to suppress immune function and increase the risk of infections, which may similarly occur due to EMF exposure.
• EMFs are suggested to facilitate the opening of voltage-gated calcium channels, causing an unhealthy increase in intracellular calcium and resultant reactive oxygen species.
• Reactive oxygen species could inhibit calcineurin, further supporting the theory that EMFs can suppress immune response.

Conclusion

This hypothesis highlights the potential health risks of EMF exposure, particularly in relation to immunosuppression and increased susceptibility to opportunistic infections, suggesting a crucial area for ongoing research.