Non-thermal disruption of β-adrenergic receptor-activated Ca2+ signalling and apoptosis in human ES-derived cardiomyocytes by microwave electric fields at 2.4 GHz

Authors: Williams CF, Hather C, Conteh JS, Zhang J, Popa RG, Owen AW, Jonas CL, Choi H, Daniel RM, Lloyd D, Porch A, George CH

Year: 2023 Apr 17

Category: Biophysics

Journal: Biochem Biophys Res Commun

DOI: 10.1016/j.bbrc.2023.04.038

URL: https://www.sciencedirect.com/science/article/pii/S0006291X23004473?via%3Dihub

Abstract

Abstract Summary

Overview

The ubiquity of wireless electronic-device connectivity has led to microwaves becoming a prevalent form of electromagnetic exposure. There is a growing body of evidence challenging the safety standards which claim wireless technologies are safe if they only consider thermal effects.

Findings

  • Microwaves at 2.4 GHz eliminated the response of human embryonic stem-cell derived cardiomyocytes (CM) to β-adrenergic receptor (β-AR) stimulation.
  • Detailed profiling linked disrupted Ca2+ signalling to spatially-clustered apoptosis under non-thermal conditions.
  • Conditions simulated were significantly above the usual environmental exposure levels, raising important concerns about potential non-thermal effects on biological tissues, especially heart tissue.

Conclusion

This study provides evidence that non-thermal effects of 2.4 GHz microwaves can significantly impact human cardiomyocyte function and survival, questioning the adequacy of current safety standards that do not consider such effects.

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