Associations Between a Polymorphism in the Rat 5-HT1A Receptor Gene Promoter Region (rs198585630) and Cognitive Alterations Induced by Microwave Exposure
Abstract
Overview
The study explores the association between the single-nucleotide polymorphism (SNP) rs198585630 in the 5-HT1A receptor and cognitive alterations following microwave exposure in rats. Key experimental conditions included a microwave frequency of 2.856 GHz and an average power density of 30 mW/cm2.
Experimental Design
- Different groups of rats and cell lines like PC12 and 293T were exposed to specified microwave conditions.
- The study duration spanned six weeks with controlled exposure intervals.
- Assessment included transcriptional activity tests in vitro and various in vivo evaluations like EEGs and memory tests.
Findings
The rs198585630 C allele in the 5-HT1A receptor promoter showed a higher transcriptional activity compared to the T allele, particularly under microwave exposure. Rats with the C allele displayed increased mRNA and protein expression of the 5-HT1A receptor.
The exposure led to notable cognitive deficits and suppressed brain electrical activity in these specific rats, highlighting a genetic susceptibility influenced by microwave radiation.
Conclusion
This research identifies the SNP rs198585630 of the 5-HT1A receptor as a crucial factor for heightened sensitivity to microwave exposure, pointing to significant implications for public health and safety concerning EMR exposure.