Abnormal Expression of Connexin43 in Cardiac Injury Induced by S-Band and X-Band Microwave Exposure in Rats

Abstract

Overview

The study focuses on the adverse effects of S-band and X-band microwave exposure on rat cardiac structure and function, highlighting its relevance in current research discussions both domestically and internationally.

Methodology

• Exposure of Wistar rats to 5 and 10 mW/cm2 S-band and X-band microwaves.
• Assessment periods at 6th hour, and 7th, 14th, 28th days post-exposure using ECG and myocardial enzyme measurement.
• Microscopic observation of myocardial structure and ultrastructure, and molecular analysis of Connexin43 (Cx43).

Findings

Post-exposure, rats exhibited increased heart rate, altered ECG wave amplitudes, and higher myocardial enzyme levels. Noteworthy is the structural and ultrastructural damage to cardiac tissues, which were both dose and frequency-dependent.

The expression and distribution of Cx43 were notably decreased and disordered, correlating with abnormalities in electrical conduction within the heart.

Conclusion

The study concludes that microwave exposure could detrimentally affect cardiac function and structure in rats, emphasizing a potential health risk to similar exposure in humans, related to changes in Cx43.