Hsp72-Based Effect and Mechanism of Microwave Radiation-Induced Cardiac Injury in Rats

Authors: Li D, Xu X, Gao Y, Wang J, Yin Y, Yao B, Zhao L, Wang H, Wang H, Dong J, Zhang J, Peng R

Year: 2022

Category: Cardiology, Biochemistry

Journal: Oxid Med Cell Longev

DOI: 10.1155/2022/7145415

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9410832

Abstract

Overview

The study focused on revealing the impacts of microwave radiation on cardiac health, especially exploring the role of heat shock protein 72 (Hsp72).

Methodology

  • Measurement of rectal temperatures and electrocardiogram (ECG) readings before and after radiation exposure.
  • Monitoring of myocardial enzymes and ion concentrations using biochemical analyses.
  • Evaluation of myocardial tissue with optical and electron microscopy.
  • Expression levels of Hsp72 investigated via Western blot and immunofluorescence methods.

Findings

Following exposure to S-wave microwave radiation at 30 mW/cm2 for 35 minutes:

  • Significant increase in rectal temperature and disruption of ECG.
  • Alterations in ion concentrations and enzyme activities related to myocardial function.
  • Observation of structural damage in myocardial tissue.
  • Increased levels of myocardial injury markers and hormones.
  • Enhanced expression of Hsp72 indicating severe stress response.

Conclusion

The study suggests that microwave radiation damages cardiac functionality through thermal and nonthermal effects, significantly implicating the potential health risks associated with electromagnetic fields.

microwave radiation cardiac injury Hsp72 rats myocardial enzymes electrocardiogram heat shock proteins
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