2450 MHz EMR exposure causes cognition deficit with mitochondrial dysfunction & activation of intrinsic pathway of apoptosis in rats

Abstract

Overview

Electromagnetic radiation (EMR) is known to influence neurobehavioral disorders, with the duration and frequency of exposure playing a critical role in the development of cognitive disorders. The present study explores the pathophysiological effects of EMR, particularly at a frequency of 2450 MHz, on cognition in relation to mitochondrial function and apoptosis.

Methodology

• Male rats were exposed to EMR frequencies of 900, 1800, and 2450 MHz for one hour daily over 28 consecutive days.
• Cognitive behavior was assessed using the novel arm entries in the Y-maze paradigm, evaluated weekly post-exposure.
• Specific examination included the effects on mitochondrial function, amyloid beta expression, and the cholinergic system within the brain's hippocampus region.

Findings

Exposure to EMR at 2450 MHz resulted in:

• Significant cognitive deficits in rats.
• Degradation of mitochondrial function and integrity.
• Increased levels of amyloid beta and activation of apoptotic factors such as caspase-9 and -3.
• A decrease in acetylcholine levels and an increase in acetylcholinesterase activity, impairing the cholinergic system.

Conclusion

Exposure to EMR at 2450 MHz is conclusively linked to cognitive deficits, with associated detrimental effects on mitochondrial function, the cholinergic system, and increase in amyloidogenesis. Recognizing these risks is crucial for health safety recommendations concerning EMR exposure.