Abstract

Overview

Electromagnetic radiation (EMR) is known to influence neurobehavioral disorders. Specific attention to the duration and frequency of exposure highlights its impact on cognitive functions.

Findings

• Male rats exposed to EMR frequencies of 900, 1800, and 2450 MHz for 1 hour daily over 28 days exhibited cognitive deficits, particularly at 2450 MHz.
• Significant loss in mitochondrial function and integrity was observed, along with increases in amyloid beta expression and cytochrome-c release.
• Activation of apoptotic factors such as caspase-9 and -3 within the hippocampus was noted, indicative of apoptosis linked to mitochondrial distress.
• The study also found impairment in the cholinergic system, highlighted by decreased acetylcholine levels and increased acetylcholinesterase activity.

Conclusion

EMR at 2450 MHz notably induces cognitive and behavioral deficits in rats, with associated pathophysiological changes in mitochondrial functions and cholinergic neurotransmission. Such findings underscore the potential health risks linked to EMR exposure and advocate for further investigations into its safe usage.