Protective effects of selenium on electromagnetic field-induced apoptosis, aromatase P450 activity, and leptin receptor expression in rat testis

Authors: Sareh Khoshbakht, Fatemeh Motejaded, Sareh Karimi, Narjes Jalilvand, Alireza Ebrahimzadeh-Bideskan

Year: 2021

Category: Biomedical Research

Journal: Iran Journal of Basic Medical Sciences

Institution: Iran J Basic Med Sci

DOI: 10.22038/ijbms.2021.45358.10554

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8087852/

Abstract

Overview

Electromagnetic fields (EMF), such as those emitted by mobile devices, may adversely affect the male reproductive system. This study explores the protective role of selenium against EMF-induced damage in rat testis.

Objectives

To investigate the effects of selenium on rat testis exposed to electromagnetic fields.

Materials and Methods

  • Subjects: Twenty-four male Wistar rats
  • Groups: EM (2100 MHz), EM/SE (2100 MHz + selenium 0.2 mg/kg), SE (selenium 0.2 mg/kg), CONT (control group)
  • Measured Parameters: Serum LH, FSH, GnRH, testosterone, leptin, aromatase levels; testis weight and volume; sperm count and quality; seminiferous tubule diameters; germinal epithelia thickness; immunoreactivity of leptin receptor and caspase-3.

Findings

The EM group displayed significant negative changes in reproductive parameters compared to the control group. Conversely, the EM/SE group, which received selenium supplementation, showed significant improvement in these parameters compared to the EM group, suggesting a protective effect of selenium.

Conclusion

Exposure to electromagnetic radiation may have detrimental effects on the male reproductive system. Selenium supplementation could mitigate these harmful effects.

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