Protective effects of selenium on electromagnetic field-induced apoptosis, aromatase P450 activity, and leptin receptor expression in rat testis
Abstract
Overview
Electromagnetic fields (EMF), such as those emitted by mobile devices, may adversely affect the male reproductive system. This study explores the protective role of selenium against EMF-induced damage in rat testis.
Objectives
To investigate the effects of selenium on rat testis exposed to electromagnetic fields.
Materials and Methods
- Subjects: Twenty-four male Wistar rats
- Groups: EM (2100 MHz), EM/SE (2100 MHz + selenium 0.2 mg/kg), SE (selenium 0.2 mg/kg), CONT (control group)
- Measured Parameters: Serum LH, FSH, GnRH, testosterone, leptin, aromatase levels; testis weight and volume; sperm count and quality; seminiferous tubule diameters; germinal epithelia thickness; immunoreactivity of leptin receptor and caspase-3.
Findings
The EM group displayed significant negative changes in reproductive parameters compared to the control group. Conversely, the EM/SE group, which received selenium supplementation, showed significant improvement in these parameters compared to the EM group, suggesting a protective effect of selenium.
Conclusion
Exposure to electromagnetic radiation may have detrimental effects on the male reproductive system. Selenium supplementation could mitigate these harmful effects.