Associations Between a Polymorphism in the Rat 5-HT1A Receptor Gene Promoter Region (rs198585630) and Cognitive Alterations Induced by Microwave Exposure

Authors: Li Haijuan, Gao Yu, Zou Yong, Qiao Simo, Zhi Weijia, Ma Lizhen, Xu Xinping, Zhao Xuelong, Zhang Junhua, Wang Lifeng, Hu Xiangjun

Year: 2022

Category: Genetics, Neuroscience

Journal: Frontiers in Public Health

Institution: Frontiers in Public Health

DOI: 10.3389/fpubh.2022.802386

URL: https://www.frontiersin.org/article/10.3389/fpubh.2022.802386

Abstract

Overview

The nervous system is a sensitive target of electromagnetic radiation (EMR). This study investigates the effects of chronic microwave exposure on cognitive functions in rats, emphasizing the involvement of the 5-HT system due to genetic polymorphisms.

Methodology

Rats and cellular models (PC12 and 293T cells) were exposed to microwaves at a frequency of 2.856 GHz and power density of 30 mW/cm². Exposures lasted for varying durations and frequencies to simulate chronic exposure.

Findings

Increased transcriptional activity was observed in the 5-HT_1A receptor promoter with the rs198585630 C allele compared to the T allele, particularly under microwave exposure.
Rats carrying the rs198585630 C allele showed higher mRNA and protein levels of the 5-HT_1A receptor, correlating with pronounced cognitive deficits and reduced brain electrical activity when exposed to microwave radiation.

Conclusion

The study suggests that the SNP rs198585630 in the 5-HT_1A receptor gene may increase susceptibility to the negative cognitive effects of microwave exposure. This highlights the potential health risks associated with electromagnetic fields and the importance of further research into genetic factors influencing EMF sensitivity.

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