Non-thermal disruption of β-adrenergic receptor-activated Ca2+ signalling and apoptosis in human ES-derived cardiomyocytes by microwave electric fields at 2.4 GHz

Authors: Williams CF, Hather C, Conteh JS, Zhang J, Popa RG, Owen AW, Jonas CL, Choi H, Daniel RM, Lloyd D, Porch A, George CH

Year: 2023 Apr 17

Category: Biophysics

Journal: Biochem Biophys Res Commun

DOI: 10.1016/j.bbrc.2023.04.038

URL: https://www.sciencedirect.com/science/article/pii/S0006291X23004473?via%3Dihub

Abstract

Overview

The study delves into the non-thermal effects of 2.4 GHz microwave exposure on human embryonic stem-cell derived cardiomyocytes. This frequency, common in wireless communications like 4G, Bluetooth, and WiFi, is critically evaluated to understand its influence on cellular functionalities and health implications.

Findings

  • Non-thermal microwave exposure disrupted normal Ca2+ signaling in response to β-adrenergic receptor (β-AR) activation.
  • Such exposure led to spatially-clustered apoptosis, indicating serious implications on cardiomyocyte function and survival.
  • The study involved extensive temperature control to isolate non-thermal effects, ensuring that observed outcomes were specifically due to microwave exposure and not thermal factors.

Conclusion

This pivotal research challenges the safety standards concerning non-thermal effects of microwaves, suggesting that existing guidelines might not adequately protect against non-thermal biological disruptions. The findings stress an immediate need for reconsideration of safety limits in light of potential non-thermal health risks.

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