Characterizing parameters and incorporating action potentials via the Hodgkin-Huxley model in a novel electric model for living cells

Abstract

Overview

To enhance our understanding of electroporation and optimize the pulses used within the frequency range of 1 kHz to 100 MHz, we introduce a novel electrical model. This model is structured as a 2D representation employing exclusively lumped elements, designed to better comprehend the dynamics of living cells' impedance variation.

Findings

• The model encapsulates the intricate dynamics of living cells' impedance variation.
• It deciphers the distribution of transmembrane potential across various orientations within living cells, critical in electroporation and cellular stimulation scenarios.
• The augmentation of the proposed electrical model with the Hodgkin-Huxley (HH) model introduces an additional dimension, enabling the exploration of muscle cell stimulation and the generation of action potentials.

Conclusion

This integration augments the model's capabilities, specifically enabling detailed investigations into intricate cellular behaviors under the influence of external electric fields, thus enhancing the model's utility significantly.