Abstract

Overview

Electromagnetic radiation (EMR) from mobile devices is a significant and growing public health concern. This study explores the neuronal impact of EMR exposure from 4G mobile phones on primary cortical neurons (PCNs) isolated from the neonatal rat cerebral cortex.

Findings

• PCNs were exposed to a frequency of 2100 MHz and a specific absorption rate of 1.6 W/Kg for 2 hours in call-answered mode.
• Hispolon (HIS) and its derivatives were used to treat the PCNs to test their protective effects against induced apoptosis.
• The study found that pyrazole derivatives helped reduce apoptosis by modulating pro and anti-apoptotic genes and lowering reactive oxygen species (ROS) levels via mitochondrial damage.

Conclusion

The findings suggest significant antioxidative and anti-apoptotic properties in the pyrazole derivatives, highlighting their potential as lead compounds for developing neuroprotective formulations against EMR-induced neuronal damage.