Exposure to Electromagnetic Fields from Mobile Phones and Fructose consumption Coalesce to Perturb Metabolic Regulators AMPK/SIRT1-UCP2/FOXO1 in Growing Rats

Authors: Tripathi R, Banerjee SK, Nirala JP, Mathur R

Year: 2023 Nov 20

Category: Biomedical Sciences

Journal: Biomed Environ Sci

Institution: Biomedical Environmental Sciences

DOI: 10.3967/bes2023.134

URL: https://www.besjournal.com/en/article/doi/10.3967/bes2023.134

Abstract

Overview

This study investigates the synergistic effects of electromagnetic fields (EMFs) emitted by mobile phones and high fructose consumption on central metabolic pathways in growing rats.

Objective

The objective is to explore the combined impact of EMFs and fructose on metabolic regulators along the AMPK/SIRT1-UCP2/FOXO1 pathway to better understand molecular mechanisms potentially leading to insulin resistance.

Methods

Weaned Wistar rats were divided into four groups with varying exposures: Normal, Exposure Only (EMFs), Fructose Only, and both EMFs and Fructose over 8 weeks.
Treatments included EMF exposure (1,760 MHz, 2 hours/day) and a 15% fructose solution.
Key metabolic functions and signaling pathways in hypothalamic and hepatic tissues were assessed.

Results

Significantly reduced expressions and activities in mitochondrial and insulin signaling markers were observed in the EMF and Fructose group when compared to controls, indicating disturbed metabolic regulation.

Conclusion

The findings indicate a potential health risk where the combination of EMF exposure and high fructose intake can disrupt important metabolic pathways in key tissues, suggesting a compounded metabolic stress that could affect insulin signaling and antioxidant defenses during crucial development phases in young rats.

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