Effects of Mobile Phone EMF on β-Amyloid-Induced Oxidative Stress in Human and Rat Primary Astrocytes

Authors: Tsoy A, Saliev T, Abzhanova E, Turgambayeva A, Kaiyrlykyzy A, Akishev M, Saparbayev S, Umbayev B, Askarova S

Year: Published online Apr 3, 2019

Category: Neuroscience

Journal: Neuroscience

DOI: 10.1016/j.neuroscience.2019.03.058

URL: https://www.sciencedirect.com/science/article/abs/pii/S0306452219302337

Abstract

Overview

Amyloid beta peptide (Aß) plays a significant role in the pathological processes linked to Alzheimer's disease (AD), primarily through oxidative stress, neuro-inflammation, and brain cell death. Despite existing treatments, controlling Aß deposition and subsequent cellular responses remains a challenge.

Findings

We studied the impact of mobile phone radiofrequency electromagnetic fields (RF-EMF) at 918 MHz on various cellular processes in human and rat primary astrocytes exposed to Aß42 and H2O2. Our observations revealed that RF-EMF:

  • Reduces cellular and mitochondrial reactive oxygen species (ROS) induced by Aß42.
  • Increases mitochondrial membrane potential (MMP) in rat primary astrocytes.
  • Suppresses activation of NADPH oxidase induced by Aß42.
  • Inhibits H2O2-induced phosphorylation of crucial kinases like p38MAPK and ERK1/2.

Conclusion

Our data supports the therapeutic potential of RF-EMF in treating conditions like Alzheimer's disease by modulating oxidative stress and other key cellular processes. It, however, also underscores the necessity for additional studies to further verify the effectiveness and safety of EMF application in AD patients.

Despite this new understanding of EMF's potential benefits, caution must be exercised when applying EMF, especially given the growing concerns about its impact on health.

Further details on the study are available at: ScienceDirect.

EMF oxidative stress Alzheimer's disease astrocytes neurodegeneration mitochondria ROS
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