Long-term radiofrequency electromagnetic fields exposure attenuates cognitive dysfunction in 5×FAD mice by regulating microglial function

Abstract

Overview

We have previously found that long-term effects of exposure to radiofrequency electromagnetic fields in 5×FAD mice with severe late-stage Alzheimer's disease reduced both amyloid-β deposition and glial activation, including microglia.

Study Method and Design

Mice were exposed to 1950 MHz radiofrequency electromagnetic fields at a specific absorption rate of 5 W/kg for 2 hours per day, 5 days a week for 6 months. Behavioral tests, along with molecular and histopathological analysis of amyloid precursor protein/amyloid-beta metabolism in brain tissue, were conducted to assess the impacts.

Findings

• Radiofrequency electromagnetic field exposure ameliorated cognitive impairment and amyloid-β deposition.
• Significant reduction in expression levels of Iba1 and CSF1R in the hippocampus compared to the control (sham-exposed) group.
• Decreased levels of genes related to microgliosis and pro-inflammatory cytokines.

Conclusion

Our findings suggest that radiofrequency electromagnetic fields could potentially serve as a therapeutic intervention for Alzheimer's disease by regulating microglial activity and reducing amyloid-β deposition-induced microgliosis.