Long-term exposure to 835 MHz RF-EMF induces hyperactivity, autophagy and demyelination in the cortical neurons of mice

Abstract

Overview

Radiofrequency electromagnetic field (RF-EMF) is globally integrated with mobile communications and has raised public concerns about its potential biological impacts.

Findings

• C57BL/6 mice were subjected to 835 MHz RF-EMF at a specific absorption rate (SAR) of 4.0 W/kg for 5 hours/day over 12 weeks to study the neural effects on the cerebral cortex, mirroring cranial exposure from mobile phones.
• Significant activation of autophagy pathways was observed in the cerebral cortex, including increased gene activation and protein production like LC3B-II and Beclin1, coupled with autolysosome accumulation.
• While the apoptotic factor Bax saw downregulation, substantial myelin sheath damage and hyperactivity-like behaviors in mice were noted, suggesting a connection to neurobehavioral disorders.

Conclusion

While the study indicates that autophagy might have a protective role for neuronal cell bodies during RF-EMF exposure, the prolonged exposure leading to demyelination points toward potential neurological or neurobehavioral disorders.