Shielding effects of myelin sheath on axolemma depolarization under transverse electric field stimulation

Authors: Ye H, Ng J.

Year: 2018 Dec 3

Category: Neuroscience

Journal: PeerJ

Institution: PeerJ

DOI: 10.7717/peerj.6020

URL: https://peerj.com/articles/6020/

Abstract

Overview

The study explores the depolarization effects of transverse electric fields on axons, focusing on the contribution of the myelin sheath in shielding against excessive polarization.

Findings

  • Quantitative calculations of transmembrane potentials (Vm) for unmyelinated axons and myelinated axons.
  • Analysis of biophysical factors such as axolemma radii and electrical conductivity influencing axonal polarization.
  • Evidence of the myelin sheath's protective "shielding effect" against transverse electric fields.
  • Discussion on how demyelination can increase axonal depolarization under transverse fields, possibly impacting the treatment of demyelination diseases.

Conclusion

This study provides crucial insights into the dynamic interactions between electric fields and neural structures, emphasizing the significant role of the myelin sheath in protecting axons during electrical stimulation. The findings also suggest avenues for further research on the implications of electric field therapy in neurological disorders.

neural activity electric fields axolemma depolarization myelin sheath demyelination electric field stimulation biophysical factors
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