Investigation of oxidative damage, antioxidant balance, DNA repair genes, and apoptosis due to radiofrequency-induced adaptive response in mice

Abstract

Overview

This study explores the effects of non-ionizing radiofrequency fields on adult mice, specifically examining whether such exposure induces an adaptive response (AR) and the molecular mechanisms involved.

Methodology

• Performed on 24 adult male Swiss-Albino mice averaging 37 g.
• Divided into four groups, two exposed to 900 MHz GSM signals, and two controls.
• Exposures were 0.339 W/kg for 4 hours per day over 7 days.
• Bleomycin was administered post-exposure to study groups to probe further effects.

Findings

• Increase in reactive oxygen species (ROS) in the RB group might trigger adaptive responses and minimum stress levels.
• Elevated levels of tumor suppressor proteins and DNA repair enzymes were noted.
• Decrement in antioxidant enzyme levels was observed, whereas apoptosis decreased due to enhanced DNA repair activities.

Conclusion

The study underscores a significant link between radiofrequency radiation exposure and molecular adaptive responses in mice, suggesting potential health implications for humans exposed to similar conditions.