Changes in Histopathology and Proteins Related to the MAPK Pathway in the Brains of Rats Exposed to Pre and Postnatal Radiofrequency Radiation Over Four Generations

Authors: Tan B, Canturk Tan F, Yalcin B, Dasdag S, Yegin K, Yay AH

Year: 2022

Category: Neuroscience

Journal: J Chem Neuroanat

DOI: 10.1016/j.jchemneu.2022.102187

URL: https://pubmed.ncbi.nlm.nih.gov/36374647/

Abstract

Overview

The development of new technologies and industry has led to an increase in the number and variety of electromagnetic field (EMF) sources, attracting research interest in their potential effects on brain health. The brain's function, highly dependent on electrical excitability, is presumed to be vulnerable to EMF exposure.

Methodology

This study explored the effects of 2450MHz continuous wave (CW) radiofrequency radiation (RFR) on brain development in fetuses and histopathological changes in female rats, as well as alterations in the hippocampal level of MAPK proteins in male rats across four generations. Rats in the exposure groups were subjected to whole-body exposure for 12 hours/day, with the exposure starting one month before fertilization.

Findings

  • Notable observations included hemorrhagic areas, irregular cellular localization, and altered vascular structures in the brains of both fetal and adult female rats in the exposed groups across all generations.
  • Increases in pERK, ptau, pJNK, and pP38 levels were noted in the brains of adult male rats in the exposed groups (p<0.005).

Conclusion

Pre and postnatal exposure to 2450MHz CW-RFR may not only influence the function of the MAPK pathway, impacting cognitive abilities such as learning and memory, but may also cause damage to both fetal and adult brain tissues. There is also a potential for effects on the brains of future generations.

EMF Radiofrequency Radiation MAPK Pathway Cognitive Processes Brain Health Histopathology Proteomics
← Back to Stats