Abstract

Overview

This study investigates the potential adaptive responses in adult mice following exposure to non-ionizing radiofrequency fields, with an emphasis on molecular mechanisms influenced by radiofrequency-induced adaptive responses.

Methodology

A total of 24 male Swiss-Albino mice, averaging 37 grams each, were divided into four groups. Two groups were exposed to a 900 MHz GSM signal, with a specific absorption rate of 0.339 W/kg, for 4 hours daily over a week. Post-exposure, some of these mice were treated with bleomycin to study further effects.

Findings

• Significant increases in reactive oxygen species and adaptive responses were observed in one group, indicating a stress response mechanism.
• Enhanced expression of DNA repair genes such as p53 and OGG-1 was noted, alongside non-significant changes in others like PARP-1 and GPx-1.
• The antioxidant enzyme levels were lower in groups showing an adaptive response, raising concerns about oxidative stress.
• Apoptosis levels were decreased in the adaptive response group, suggesting a reduction in cell death due to enhanced DNA repair mechanisms.

Conclusion

The data suggests that exposure to RF radiation can trigger protective reactions in mice, which may enable the survival of cells facing external stressors like bleomycin, raising important considerations for the health effects of RF exposure.