Changes in Histopathology and Proteins Related to the MAPK Pathway in the Brains of Rats Exposed to Pre and Postnatal Radiofrequency Radiation Over Four Generations
Abstract
Overview
The increased exposure to electromagnetic fields (EMF) from new technologies raises significant concerns regarding the effects on brain health, particularly because the brain's function heavily relies on electrical excitability.
Study Details
This study focuses on examining the effects of pre and postnatal exposure to 2450MHz continuous wave radiofrequency radiation (RFR) across four generations of rats, analyzing fetal brain development, histopathological changes in female rats, and MAPK protein levels in male rats’ hippocampi.
- Key methods included whole-body exposure to radiofrequency radiation for 12 hours/day, haematoxylin eosin staining, and Western Blotting to assess MAPK protein levels.
Findings
Significant findings showed that EMF exposure led to hemorrhagic areas, irregular cellular localization, and altered vascular structures in both fetal and adult brain tissues in all generations studied. Furthermore, proteins like pERK, ptau, pJNK, and pP38 were found increased in male brains, indicating substantial changes in brain function related to the MAPK pathway, which impacts learning, memory, and overall cognitive processes.
Conclusion
These observed changes suggest that EMF exposure could severely affect brain health, potentially damaging both the fetus and adult brain tissues. Moreover, these impacts may carry over into future generations, amplifying the importance of understanding EMF's biological effects relative to public health.