Protective effect of paricalcitol in rat testicular damage induced by subchronic 1800 MHz radiofrequency radiation

Authors: Demirbağ B, Aktaş S, Çömelekoğlu Ü, Kara İ, Yildirim M, Yildirim DD

Year: 2023 Sep 12

Category: Biochemistry and Biophysics

Journal: Biochem Biophys Res Commun

DOI: 10.1016/j.bbrc.2023.09.024

URL: https://pubmed.ncbi.nlm.nih.gov/37717340/

Abstract

Overview

In this study, researchers investigated the potential protective effects of paricalcitol in alleviating testicular damage caused by exposure to 1800 MHz radiofrequency radiation (RFR) in male Sprague Dawley rats.

Methodology

The rats, aged 8-10 weeks, were divided into four groups: a control group, a group exposed to RFR, a group treated with paricalcitol, and a group exposed to both RFR and paricalcitol. Testicular tissue was examined using histological and biochemical methodologies over a 30-day period.

Findings

Exposure to RFR led to noticeable ultrastructural changes in testicular cells, which were significantly mitigated by paricalcitol treatment.
Statistical analyses revealed no significant changes in seminiferous tubule diameters and germinal epithelial thickness across the groups.
The combined treatment group (RFR + P) showed increased levels of superoxide dismutase and catalase activities, along with a decrease in malondialdehyde levels, indicating reduced oxidative stress.

Conclusion

The study highlights that paricalcitol has a protective role in reducing testicular damage from subchronic exposure to RFR, suggesting potential therapeutic strategies for mitigating RFR-induced reproductive harm.

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