Effect of exposure to 1800 MHz RFR on epidermal growth factor, caspase-3, Hsp27 and p38MAPK gene expressions in the rat eye

Abstract

Overview

This study examines the impact of 1800 MHz radiofrequency electromagnetic fields (RF-EMF) on crucial gene expressions in rat ocular cells, contributing to our understanding of EMF exposure effects on biological tissues.

Objective

The primary aim was to investigate changes in gene expressions related to stress responses and growth factors in the rat eye after exposure to RF-EMF. Specifically, the focus was on heat shock protein 27 (Hsp27), p38 mitogen-activated protein kinase (p38MAPK), epidermal growth factor receptor (EGFR), and caspase-3.

Methods

• A total of 37 female Wistar albino rats were utilized, segregated into three groups.
• The exposed group experienced 1800 MHz RF-EMF at 6.8 ± 0.1 V/m and 0.06 W/kg SAR for two hours daily over eight weeks.
• Comparative analysis was made with a sham group and another control group, under similar conditions minus the RF-EMF exposure.

Findings

Significant upregulation was observed in caspase-3 and p38MAPK gene expressions within ocular tissues post RF-EMF exposure (p < 0.05), pointing to cellular stress and possible damage mechanisms being activated.

Conclusion

The results articulate a clear link between RF-EMF exposure and activation of specific gene expressions associated with cellular damage in ocular tissues. This emphasizes the potential health risks associated with RF-EMF exposure.