Abstract

Abstract Summary

Overview

In prior research, the impact of radiofrequency (RF) electromagnetic fields (EMF) on DNA integrity was scrutinized, with findings suggesting a resemblance to the adaptive response—a key phenomenon in radiobiology where exposure to minimal stress enhances resistance to subsequent stress.

Findings

• The study explored the effects of radiofrequency at 1950 MHz on the culture medium of SH-SY5Y neuroblastoma cells.
• It was observed that non-exposed cells recipient of the medium from exposed cells showed decreased DNA damage induced by menadione—a significant revelation pointing towards a bystander effect where non-ionizing radiation influences unexposed cells.
• Simultaneously, a decrease in DNA damage was also evident in cells directly exposed to EMF under the same conditions, supporting the adaptive response framework.
• Furthermore, an increase in heat shock protein 70 (hsp70) was noted in the culture medium post RF exposure while its intracellular levels remained unchanged, highlighting the potential role of hsp70 in mediating RF-EMF's biological effects.

Conclusion

This study presents compelling evidence linking RF-EMF exposure to a protective effect against DNA damage through bystander effects and adaptive responses, with the hsp70 pathway identified as a crucial avenue for further exploration regarding RF-EMF interaction with cellular systems.