Abstract

Overview

Exposure to radiofrequency electromagnetic fields (RF-EMF, 100 kHz - 300 GHz) is omnipresent due to wireless communication technologies, with possible health implications, including cancer. The International Agency for Research on Cancer classifies RF-EMF as a potential human carcinogen, albeit with limited evidence. This systematic review aims to address gaps in knowledge about the genotoxic effects of RF-EMF through experimental studies.

Objectives

• Develop a protocol for systematically reviewing experimental in vitro studies investigating the genotoxic effects of RF-EMF.
• Determine the connection between RF-EMF exposure and genotoxicity.

Methods

Adhering to the National Toxicology Program-Office of Health Assessment and Translation (NTP-OHAT) guidelines, this review will include only experimental in vitro studies published in English, with no publication date restrictions, and will follow predefined procedures for systematic reviews.

Data Extraction and Synthesis

Findings from included studies will be qualitatively and quantitatively synthesized, including potential meta-analyses if studies are homogenous in key variables like exposure characteristics and endpoints.

Risk of Bias and Evidence Appraisal

The study's internal validity will be assessed using the adapted NTP-OHAT Risk of Bias Tool, and confidence in the evidence will be evaluated using a GRADE-based approach tailored for animal studies.

Funding

The review is supported by the Italian Workers' Compensation Authority and falls under broader research on the carcinogenic potential of RF-EMF.