Abstract

Abstract Overview

This study examines the impact of extremely low frequency magnetic fields (ELF-MF) on SH-SY5Y human neuroblastoma cells, specifically exploring the fields' suspect role in promoting malignant progression as classified by the International Agency for Research on Cancer.

Key Findings

• ELF-MF potentially provides survival advantages to cancer cells via activation of cytoprotective pathways, particularly antioxidative and detoxification systems.
• The research focused on the response of neuroblastoma cells to 50 Hz, 1 mT ELF magnetic field, revealing enhanced proliferation supported by improved defense against reactive oxygen species (ROS) and xenobiotics.
• Exposure led to the activation of redox-responsive antioxidative and detoxification cytoprotective pathways tied to more aggressive behavior of neuroblastoma cells.
• In-depth analysis showed upregulation in major sirtuins and increased activity of the erythroid 2-related nuclear transcription factor 2 (NRF2).
• Further, even lower exposures (100 µT) may alter cancer cell behaviors and responses to clinically relevant drugs, such as doxorubicin.

Conclusion

The findings underscore the potential health risks associated with ELF-MF exposure, particularly its possible role in malignancy enhancement and resistance to chemotherapy in neuroblastoma cells. Such concerns highlight the need for continued evaluation of EMF safety standards and protection measures for public health.