ELF MF and Redox-Responsive Pathways Linked to Cancer Drug Resistance: Insights from Co-Exposure-Based In Vitro Studies

Authors: Falone S, Santini S, Cordone V, Di Emidio G, Tatone C, Caachio M, Amicarelli F

Year: 23 Feb 2018

Category: Oncology

Journal: Frontiers in Public Health

DOI: 10.3389/fpubh.2018.00033

URL: https://www.frontiersin.org/articles/10.3389/fpubh.2018.00033/full

Abstract

Overview

Electrical devices used in clinical settings and households generate extremely low-frequency magnetic fields (ELF-MF) that pose potential carcinogenic risks. This review paper explores how ELF-MF may influence cancer progression and drug resistance pathways without directly altering DNA.

Findings

ELF-MF is suspected of activating intracellular signaling and detoxification systems related to oxidative stress, potentially offering tumors a proliferative and survival benefit.
In-depth investigation of the role of ELF-MF in promoting multi-drug resistance in tumor cells is critical. This entails examining redox-responsive mediators and their interaction with ELF-MF alongside reactive oxygen species-producing agents.

Conclusion

The study outlines significant molecular targets that may help mitigate the interactions between ELF-MF and cancerous tissue, suggesting pathways through which ELF-MF could impact tumor behavior and treatment resistance.

ELF-MF cancer drug resistance redox-responsive pathways tumor cells oxidative stress carcinogenic

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