Effect of static magnetic field on DNA synthesis: The interplay between DNA chirality and magnetic field left- right asymmetry

Authors: Yang X, Li Z, Polyakova T, Dejneka A, Zablotskii V, Zhang X

Year: 2020 Mar 7

Category: Biophysics

Journal: FASEB Bioadv

DOI: 10.1096/fba.2019-00045

URL: https://www.ncbi.nlm.nih.gov/pubmed/32259051

Abstract

Overview

Interactions between magnetic fields (MFs) and living cells can elicit diverse cellular responses. However, the specific mechanisms involved at the intracellular level remain unclear.

Mechanism and Findings

The study explores the influence of two pivotal broken symmetries:

  • Left-right (LR) asymmetry of MFs
  • Chirality of DNA molecules, which bear electric charges and are influenced by the Lorentz force within a MF.

This research has uncovered that DNA synthesis is affected by the chirality-driven effects of static magnetic fields (SMFs), demonstrating a discrepancy in DNA synthesis rates between upward and downward directed SMFs. This difference potentially leads to unequal cell proliferation in these two directions.

Conclusion

The interplay between DNA chirality and the LR asymmetry of MFs offers critical insights into various MF-induced biological phenotypes, laying the groundwork for further understanding and potential applications in medical and biological research.

magnetic fields DNA synthesis cell proliferation cellular responses static magnetic fields chirality Lorentz force
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