Extremely low-frequency electromagnetic field (ELF-EMF) induces alterations in epigenetic regulation in the myometrium - An in vitro study

Authors: Franczak A, Drzewiecka EM, Kozlowska W, Zmijewska A, Wydorski PJ

Year: 2023 Feb 7

Category: Epigenetics

Journal: Theriogenology

DOI: 10.1016/j.theriogenology.2023.02.005

URL: https://pubmed.ncbi.nlm.nih.gov/36806924/

Abstract

Overview

The study explores how extremely low-frequency electromagnetic fields (ELF-EMFs) impact epigenetic regulation within the myometrium by testing its effects on porcine myometrium tissue slices during in vitro conditions.

Findings

  • Analysis on the ELF-EMF's influence over gene expression promoters and DNA methyltransferases.
  • ELF-EMF increased the expression of DNA methyltransferase 1 (DNMT1) and decreased DNA (cytosine-5)-methyltransferase 3a (DNMT3a) mRNA transcript and protein levels.
  • Induced increases in genomic DNA methylation levels.
  • Provided evidence suggesting alterations in the transcriptional activity of methylated and unmethylated variants of certain genes.

Conclusion

The data indicates that ELF-EMF exposure can disturb epigenetic mechanisms, potentially affecting transcriptomic alterations in the myometrium. This raises implications for the effects of ELF-EMF on health, linking it to potential risks associated with epigenetic dysregulation.

ELF-EMF epigenetic regulation myometrium gene expression DNA methylation
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