Analyzing the impact of 900 MHz EMF short-term exposure to the expression of 667 miRNAs in human peripheral blood cells

Authors: Andreas Lamkowski, Matthias Kreitlow, Jörg Radunz, Martin Willenbockel, Marcus Stiemer, Lars Ole Fichte, Carl Friedrich Rädel, Matthäus Majewski, Patrick Ostheim, Matthias Port, Michael Abend

Year: 2021 Feb 24

Category: Biomedical Research

Journal: Sci Rep

DOI: 10.1038/s41598-021-82278-1

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904780/

Abstract

Overview

In modern society, exposure to electromagnetic fields (EMF) is common, primarily from wireless communication technologies. This study explores the biological effects of EMF, particularly at non-thermal levels, on human blood cells, employing advanced techniques to examine miRNA expression changes.

Methodology & Findings

  • Utilized a quantitative real-time PCR platform to evaluate changes in 667 miRNAs post-exposure to 900 MHz EMF.
  • Exposure durations included 0, 30, 60, and 90 minutes, using blood cells from 5 male donors.
  • Significant findings were confirmed through comparison with control data adjusted for potential hyperthermia effects.
  • Analysis highlighted two key miRNAs showing significant downregulation post EMF exposure relative to controls.

Conclusion

Despite identifying some miRNA expressions associated with specific exposure times, no conclusive evidence shows a consistent change in miRNA levels due to EMF exposure. The study also explored individual variability in response to EMF, finding no substantial evidence to support the existence of EMF-sensitive individuals.

EMF miRNAs human blood cells 900 MHz ex vivo in vitro non-thermal effects electromagnetic exposure
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