Stereological Study on the Effect of Carnosine on Purkinje Cells in the Cerebellum of Rats Exposed to 900 MHz Electromagnetic Field

Authors: Arslan A, Acer N, Kesici H, Sonmez MF, Ertekin T, Gultekin M, Dagdelen U, Saracoglu OG

Year: 2021 Aug 28

Category: Neuroscience

Journal: Turk Neurosurg

Institution: Turkish Neurosurgery

DOI: 10.5137/1019-5149.JTN.35313-21.2

URL: http://www.turkishneurosurgery.org.tr/pdf/JTNEPUB_35313_online.pdf

Abstract

Overview

The objective of this research was to explore the protective effects of Carnosine on Purkinje neurons in the cerebellum of rats exposed to electromagnetic fields (EMF). These fields have been indicated to reduce neuronal numbers, potentially posing neurological risks.

Aim

The study aimed to assess how Carnosine impacts Purkinje neurons under the influence of a 900 MHz electromagnetic field, which has shown potential detrimental effects on neuronal health.

Material and Methods

  • The experiment involved 24 rats, split into three groups: a control group, an electromagnetic field exposed group, and a combined treatment group receiving Carnosine while exposed to the electromagnetic field.
  • Exposure involved a 900 MHz EMF for one hour daily over 28 days followed by a stereological analysis on the cerebellar sections to count Purkinje cells.

Findings

The study highlighted significant neuronal loss in the group exposed to EMF alone but showed an increase in neuron survival in the group treated with Carnosine. This suggests Carnosine’s protective efficacy against EMF-induced neural damage.

Conclusion

It was concluded that EMF exposure notably decreases the number of Purkinje cells, positing potential neurological risks, but Carnosine offers protection against such damage. This underscores the importance of further investigation into protective agents against EMF exposure.

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