Possible effects of different doses of 2.1 GHz electromagnetic radiation on learning, and hippocampal levels of cholinergic biomarkers in Wistar rats

Authors: Çiğdem Gökçek-Saraç, Güven Akçay, Serdar Karakurt, Kayhan Ateş, Şükrü Özen, Narin Derin

Year: 2020 Dec 1

Category: Biomedical Research

Journal: Electromagn Biol Med

DOI: 10.1080/15368378.2020.1851251

URL: https://pubmed.ncbi.nlm.nih.gov/33259237/

Abstract

Overview

The study investigates the impact of short-term exposure to 2.1 GHz radiofrequency electromagnetic radiation (RF-EMR) at different doses on rat behavior and hippocampal biomarkers.

Methodology

  • Rats divided into three groups: one sham-exposed, two exposed to 45 V/m and 65 V/m doses respectively for one week.
  • Behavioral assessments done using object location and Y-maze tasks.
  • Hippocampal biomarkers such as AChE, ChAT, and VAChT tested via Western Blotting and Real-Time PCR.

Findings

Significant impairments in behavioral tasks and lower levels of hippocampal cholinergic biomarkers were noted particularly in rats exposed to 65 V/m, suggesting a dose-dependent effect.

Conclusion

The results indicate a potential risk of short-term exposure to 2.1 GHz RF-EMR to cognitive functions and neural biochemistry in rats, highlighting the need for further research on the influence of RF-EMR on the central cholinergic system.

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